業績

PUBLICATION LIST

2017

1. Shibata, Y., F. Tokunaga, E. Goto, G. Komatsu, J. Gohda, Y. Saeki, K. Tanaka, H. Takahashi, T. Sawasaki, S. Inoue, H. Oshiumi, T. Seya, H. Nakano, Y. Tanaka, K. Iwai, and J.I. Inoue. 2017. HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains. PLoS Pathog 13:e1006162.

 

2. Piao, X., S. Yamazaki, S. Komazawa-Sakon, S. Miyake, O. Nakabayashi, T. Kurosawa, T. Mikami, M. Tanaka, N. Van Rooijen, M. Ohmuraya, A. Oikawa, Y. Kojima, S. Kakuta, Y. Uchiyama, M. Tanaka, and H. Nakano. 2017. Depletion of myeloid cells exacerbates hepatitis and induces an aberrant increase in histone H3 in mouse serum. Hepatology 65:237-252.

 

3. Nishina, T., Y. Deguchi, R. Miura, S. Yamazaki, Y. Shinkai, Y. Kojima, K. Okumura, Y. Kumagai, and H. Nakano. 2017. Critical contribution of nuclear factor erythroid 2-related factor 2 (NRF2) to electrophile-induced Interleukin-11 production. J Biol Chem 292:205-216.

 

4. Nakano, H., Piao, X., Shindo, R., and Komazawa-Sakon, S. 2017. Cellular FLICE-Inhibitory Protein Regulates Tissue Homeostasis. Curr Top Microbiol Immunol 403, 119-141.

 

5. Yamazaki S, Tanaka Y, Araki H, Kohda A, Sanematsu F, Arasaki T, Duan X, Miura F, Katagiri T, Shindo R, Nakano H, Ito T, Fukui Y, Endo S, Sumimoto H. The AP-1 transcription factor JunB is required for Th17 cell differentiation. Sci Rep in press.

 

著書

1.Nagata, S. and Nakano, H., Eds. Apoptotic and Non-apoptotic cell death. Curr Top Microbiol Immunol 403, 1-183, Springer, Switzerland

2016

1. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Nakano H, et al. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12: 1-222

 

2. Shindo R, Yamazaki S, Ohmuraya M, Araki K, Nakano H. Short form FLICE-inhibitory protein promotes TNFalpha-induced necroptosis in fibroblasts derived from CFLARs transgenic mice. Biochem Biophys Res Commun 2016;480:23-28.

 

3. Sakata K, Araki K, Nakano H, Nishina T, Komazawa-Sakon S, Murai S, Lee GE, Hashimoto D, Suzuki C, Uchiyama Y, Notohara K, Gukovskaya AS, Gukovsky I, Yamamura KI, Baba H, Ohmuraya M. Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome.Sci Rep 2016;6:37200.

 

日本語総説

進藤綾大、中野裕康
ネクロプトーシスの分子機構とその意義
実験医学増刊号「細胞死—新しい実行メカニズムの謎に迫り疾患を理解する」田中正人、中野裕康 編集, 34:24-28, 2016.

2015

1. Tsuchiya Y, Nakabayashi O, Nakano H.(2015)FLIP the Switch: Regulation of Apoptosis and Necroptosis by cFLIP. Int J Mol Sci.

 

日本語総説

土屋勇一、中野裕康
慢性炎症と悪性腫瘍(がん)
臨床免疫・アレルギー科 63:1-6, 2015.

ネクロプトーシスによる生体応答制御
進藤綾大、中野裕康
臨床免疫・アレルギー科 63:401-405, 2015.


山崎 創
臨床免疫・アレルギー科 63:466-471, 2015.

2014

1. Nagashima, H., Okuyama, Y., Asao, A., Kawabe, T., Yamaki, S., Nakano, H., Croft, M., Ishii, N., and So, T. (2014) The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6. Nat Immunol 15, 449-456

 

2. Bian, Z., Dai, J., Nakano, H., Guan, H., Yuan, Y., Gan, L., Zhou, H., Zong, J., Zhang, Y., Li, F., Yan, L., Shen, D., Li, H., and Tang, Q. (2014) Disuption of Tumor Necrosis Factor Receptor Associated Factor 5 Exacerbates Pressure Overload Cardiac Hypertrophy and Fibrosis. J Cell Biochem 115, 349-358

 

日本語総説

中野裕康
cFLIPの生体の恒常性維持に置ける役割
生化学, 86:400-403, 2014.

2013

1. Wang, L., Lu, Y., Guan, H., Jiang, D., Guan, Y., Zhang, X., Nakano, H., Zhou, Y., Zhang, Y., Yang, L., and Li, H. (2013) Tumor Necrosis Factor Receptor Associated Factor 5 is an Essential Mediator of Ischemic Brain Infarction. J Neurochem 126, 400-414

 

2. Speight, P., Nakano, H., Kelley, T. J., Hinz, B., and Kapus, A. (2013) Differential topical susceptibility to TGFbeta in intact and injured regions of the epithelium: key role in myofibroblast transition. Mol Biol Cell 24, 3326-3336

 

3. Shindo, R., Kakehashi, H., Okumura, K., Kumagai, Y., and Nakano, H. (2013) Critical contribution of oxidative stress to TNFalpha-induced necroptosis downstream of RIPK1 activation. Biochem Biophys Res Commun 436, 212-216

 

4. Ly, D. L., Waheed, F., Lodyga, M., Speight, P., Masszi, A., Nakano, H., Hersom, M., Pedersen, S. F., Szaszi, K., and Kapus, A. (2013) Hyperosmotic stress regulates the distribution and stability of myocardin-related transcription factor, a key modulator of the cytoskeleton. Am J Physiol Cell Physiol 304, C115-127

 

5. Ashida, H., Nakano, H., and Sasakawa, C. (2013) Shigella IpaH0722 E3 Ubiquitin Ligase Effector Targets TRAF2 to Inhibit PKC-NF-kappaB Activity in Invaded Epithelial Cells. PLoS Pathog9, e1003409

 

日本語総説

中野裕康
代償性増殖と酸化ストレス
化学と生物, 51:2-6, 2013

中野裕康、朴雪花
c-FLIPの腸管や肝臓の恒常性維持における役割
実験医学,30:1290-1294,2013

仁科隆史、中野裕康
細胞死と代償性増殖
医学のあゆみ,246:419-425,2013

仁科隆史、中野裕康
細胞死に伴う酸化ストレスの生体の恒常性維持における役割
医学の歩み, 247:949-954, 2013.

2012

1. Piao, X., Komazawa-Sakon, S., Nishina, T., Koike, M., Piao, J. H., Ehlken, H., Kurihara, H., Hara, M., Van Rooijen, N., Schutz, G., Ohmuraya, M., Uchiyama, Y., Yagita, H., Okumura, K., He, Y. W., and Nakano, H. (2012) c-FLIP Maintains Tissue Homeostasis by Preventing Apoptosis and Programmed Necrosis. Sci Signal 5, ra93.Selected by "Faculty of 1000"

 

2. Piao, J. H., Yagita, H., Okumura, K., and Nakano, H. (2012) Aberrant accumulation of interleukin-10-secreting neutrophils in TRAF2-deficient mice. Immunol Cell Biol 90, 881-888

 

3. Nishina, T., Komazawa-Sakon, S., Yanaka, S., Piao, X., Zheng, D. M., Piao, J. H., Kojima, Y., Yamashina, S., Sano, E., Putoczki, T., Doi, T., Ueno, T., Ezaki, J., Ushio, H., Ernst, M., Tsumoto, K., Okumura, K., and Nakano, H. (2012) Interleukin-11 links oxidative stress and compensatory proliferation. Sci Signal 5, ra5

 

4. Minami, T., Kuwahara, K., Nakagawa, Y., Takaoka, M., Kinoshita, H., Nakao, K., Kuwabara, Y., Yamada, Y., Yamada, C., Shibata, J., Usami, S., Yasuno, S., Nishikimi, T., Ueshima, K., Sata, M., Nakano, H., Seno, T., Kawahito, Y., Sobue, K., Kimura, A., Nagai, R., and Nakao, K. (2012) Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodelling in mice. EMBO J 31, 4428-4440

 

5. Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., Ahn, H. J., Ait-Mohamed, O., Ait-Si-Ali, S., Akematsu, T., Akira, S., Al-Younes, H. M., Al-Zeer, M. A., Albert, M. L., Albin, R. L., Alegre-Abarrategui, J., Aleo, M. F., Alirezaei, M., Almasan, A., Almonte-Becerril, M., Amano, A., Amaravadi, R., Amarnath, S., Amer, A. O., Andrieu-Abadie, N., Anantharam, V., Ann, D. K., Anoopkumar-Dukie, S., Aoki, H., Apostolova, N., Auberger, P., Baba, M., Backues, S. K., Baehrecke, E. H., Bahr, B. A., Bai, X. Y., Bailly, Y., Baiocchi, R., Baldini, G., Balduini, W., Ballabio, A., Bamber, B. A., Bampton, E. T., Banhegyi, G., Bartholomew, C. R., Bassham, D. C., Bast, R. C., Jr., Batoko, H., Bay, B. H., Beau, I., Bechet, D. M., Begley, T. J., Behl, C., Behrends, C., Bekri, S., Bellaire, B., Bendall, L. J., Benetti, L., Berliocchi, L., Bernardi, H., Bernassola, F., Besteiro, S., Bhatia-Kissova, I., Bi, X., Biard-Piechaczyk, M., Blum, J. S., Boise, L. H., Bonaldo, P., Boone, D. L., Bornhauser, B. C., Bortoluci, K. R., Bossis, I., Bost, F., Bourquin, J. P., Boya, P., Boyer-Guittaut, M., Bozhkov, P. V., Brady, N. R., Brancolini, C., Brech, A., Brenman, J. E., Brennand, A., Bresnick, E. H., Brest, P., Bridges, D., Bristol, M. L., Brookes, P. S., Brown, E. J., Brumell, J. H., Brunetti-Pierri, N., Brunk, U. T., Bulman, D. E., Bultman, S. J., Bultynck, G., Burbulla, L. F., Bursch, W., Butchar, J. P., Buzgariu, W., Bydlowski, S. P., Cadwell, K., Cahova, M., Cai, D., Cai, J., Cai, Q., Calabretta, B., Calvo-Garrido, J., Camougrand, N., Campanella, M., Campos-Salinas, J., Candi, E., Cao, L., Caplan, A. B., Carding, S. R., Cardoso, S. M., Carew, J. S., Carlin, C. R., Carmignac, V., Carneiro, L. A., Carra, S., Caruso, R. A., Casari, G., Casas, C., Castino, R., Cebollero, E., Cecconi, F., Celli, J., Chaachouay, H., Chae, H. J., Chai, C. Y., Chan, D. C., Chan, E. Y., Chang, R. C., Che, C. M., Chen, C. C., Chen, G. C., Chen, G. Q., Chen, M., Chen, Q., Chen, S. S., Chen, W., Chen, X., Chen, X., Chen, X., Chen, Y. G., Chen, Y., Chen, Y., Chen, Y. J., Chen, Z., Cheng, A., Cheng, C. H., Cheng, Y., Cheong, H., Cheong, J. H., Cherry, S., Chess-Williams, R., Cheung, Z. H., Chevet, E., Chiang, H. L., Chiarelli, R., Chiba, T., Chin, L. S., Chiou, S. H., Chisari, F. V., Cho, C. H., Cho, D. H., Choi, A. M., Choi, D., Choi, K. S., Choi, M. E., Chouaib, S., Choubey, D., Choubey, V., Chu, C. T., Chuang, T. H., Chueh, S. H., Chun, T., Chwae, Y. J., Chye, M. L., Ciarcia, R., Ciriolo, M. R., Clague, M. J., Clark, R. S., Clarke, P. G., Clarke, R., Codogno, P., Coller, H. A., Colombo, M. I., Comincini, S., Condello, M., Condorelli, F., Cookson, M. R., Coombs, G. H., Coppens, I., Corbalan, R., Cossart, P., Costelli, P., Costes, S., Coto-Montes, A., Couve, E., Coxon, F. P., Cregg, J. M., Crespo, J. L., Cronje, M. J., Cuervo, A. M., Cullen, J. J., Czaja, M. J., D'Amelio, M., Darfeuille-Michaud, A., Davids, L. M., Davies, F. E., De Felici, M., de Groot, J. F., de Haan, C. A., De Martino, L., De Milito, A., De Tata, V., Debnath, J., Degterev, A., Dehay, B., Delbridge, L. M., Demarchi, F., Deng, Y. Z., Dengjel, J., Dent, P., Denton, D., Deretic, V., Desai, S. D., Devenish, R. J., Di Gioacchino, M., Di Paolo, G., Di Pietro, C., Diaz-Araya, G., Diaz-Laviada, I., Diaz-Meco, M. T., Diaz-Nido, J., Dikic, I., Dinesh-Kumar, S. P., Ding, W. X., Distelhorst, C. W., Diwan, A., Djavaheri-Mergny, M., Dokudovskaya, S., Dong, Z., Dorsey, F. C., Dosenko, V., Dowling, J. J., Doxsey, S., Dreux, M., Drew, M. E., Duan, Q., Duchosal, M. A., Duff, K., Dugail, I., Durbeej, M., Duszenko, M., Edelstein, C. L., Edinger, A. L., Egea, G., Eichinger, L., Eissa, N. T., Ekmekcioglu, S., El-Deiry, W. S., Elazar, Z., Elgendy, M., Ellerby, L. M., Eng, K. E., Engelbrecht, A. M., Engelender, S., Erenpreisa, J., Escalante, R., Esclatine, A., Eskelinen, E. L., Espert, L., Espina, V., Fan, H., Fan, J., Fan, Q. W., Fan, Z., Fang, S., Fang, Y., Fanto, M., Fanzani, A., Farkas, T., Farre, J. C., Faure, M., Fechheimer, M., Feng, C. G., Feng, J., Feng, Q., Feng, Y., Fesus, L., Feuer, R., Figueiredo-Pereira, M. E., Fimia, G. M., Fingar, D. C., Finkbeiner, S., Finkel, T., Finley, K. D., Fiorito, F., Fisher, E. A., Fisher, P. B., Flajolet, M., Florez-McClure, M. L., Florio, S., Fon, E. A., Fornai, F., Fortunato, F., Fotedar, R., Fowler, D. H., Fox, H. S., Franco, R., Frankel, L. B., Fransen, M., Fuentes, J. M., Fueyo, J., Fujii, J., Fujisaki, K., Fujita, E., Fukuda, M., Furukawa, R. H., Gaestel, M., Gailly, P., Gajewska, M., Galliot, B., Galy, V., Ganesh, S., Ganetzky, B., Ganley, I. G., Gao, F. B., Gao, G. F., Gao, J., Garcia, L., Garcia-Manero, G., Garcia-Marcos, M., Garmyn, M., Gartel, A. L., Gatti, E., Gautel, M., Gawriluk, T. R., Gegg, M. E., Geng, J., Germain, M., Gestwicki, J. E., Gewirtz, D. A., Ghavami, S., Ghosh, P., Giammarioli, A. M., Giatromanolaki, A. N., Gibson, S. B., Gilkerson, R. W., Ginger, M. L., Goncu, E., Gongora, C., Gonzalez, C. D., Gonzalez, R., Gonzalez-Estevez, C., Gonzalez-Polo, R. A., Gonzalez-Rey, E., Gorbunov, N. V., Gorski, S., Goruppi, S., Gottlieb, R. A., Gozuacik, D., Granato, G. E., Grant, G. D., Green, K. N., Gregorc, A., Gros, F., Grose, C., Grunt, T. W., Gual, P., Guan, J. L., Guan, K. L., Guichard, S. M., Gukovskaya, A. S., Gukovsky, I., Gunst, J., Gustafsson, A. B., Halayko, A. J., Hale, A. N., Halonen, S. K., Hamasaki, M., Han, F., Han, T., Hancock, M. K., Hansen, M., Harada, H., Harada, M., Hardt, S. E., Harper, J. W., Harris, A. L., Harris, J., Harris, S. D., Hebert, M. J., Heidenreich, K. A., Helfrich, M. H., Helgason, G. V., Henske, E. P., Herman, B., Herman, P. K., Hetz, C., Hilfiker, S., Hill, J. A., Hocking, L. J., Hofman, P., Hofmann, T. G., Hohfeld, J., Holyoake, T. L., Hong, M. H., Hood, D. A., Hotamisligil, G. S., Houwerzijl, E. J., Hoyer-Hansen, M., Hu, B., Hu, C. A., Hu, H. M., Hua, Y., Huang, C., Huang, J., Huang, S., Huang, W. P., Huber, T. B., Huh, W. K., Hung, T. H., Hupp, T. R., Hur, G. M., Hurley, J. B., Hussain, S. N., Hussey, P. J., Hwang, J. J., Hwang, S., Ichihara, A., Ilkhanizadeh, S., Inoki, K., Into, T., Iovane, V., Iovanna, J. L., Ip, N. Y., Isaka, Y., Ishida, H., Isidoro, C., Isobe, K., Iwasaki, A., Izquierdo, M., Izumi, Y., Jaakkola, P. M., Jaattela, M., Jackson, G. R., Jackson, W. T., Janji, B., Jendrach, M., Jeon, J. H., Jeung, E. B., Jiang, H., Jiang, H., Jiang, J. X., Jiang, M., Jiang, Q., Jiang, X., Jiang, X., Jimenez, A., Jin, M., Jin, S., Joe, C. O., Johansen, T., Johnson, D. E., Johnson, G. V., Jones, N. L., Joseph, B., Joseph, S. K., Joubert, A. M., Juhasz, G., Juillerat-Jeanneret, L., Jung, C. H., Jung, Y. K., Kaarniranta, K., Kaasik, A., Kabuta, T., Kadowaki, M., Kagedal, K., Kamada, Y., Kaminskyy, V. O., Kampinga, H. H., Kanamori, H., Kang, C., Kang, K. B., Kang, K. I., Kang, R., Kang, Y. A., Kanki, T., Kanneganti, T. D., Kanno, H., Kanthasamy, A. G., Kanthasamy, A., Karantza, V., Kaushal, G. P., Kaushik, S., Kawazoe, Y., Ke, P. Y., Kehrl, J. H., Kelekar, A., Kerkhoff, C., Kessel, D. H., Khalil, H., Kiel, J. A., Kiger, A. A., Kihara, A., Kim, D. R., Kim, D. H., Kim, D. H., Kim, E. K., Kim, H. R., Kim, J. S., Kim, J. H., Kim, J. C., Kim, J. K., Kim, P. K., Kim, S. W., Kim, Y. S., Kim, Y., Kimchi, A., Kimmelman, A. C., King, J. S., Kinsella, T. J., Kirkin, V., Kirshenbaum, L. A., Kitamoto, K., Kitazato, K., Klein, L., Klimecki, W. T., Klucken, J., Knecht, E., Ko, B. C., Koch, J. C., Koga, H., Koh, J. Y., Koh, Y. H., Koike, M., Komatsu, M., Kominami, E., Kong, H. J., Kong, W. J., Korolchuk, V. I., Kotake, Y., Koukourakis, M. I., Kouri Flores, J. B., Kovacs, A. L., Kraft, C., Krainc, D., Kramer, H., Kretz-Remy, C., Krichevsky, A. M., Kroemer, G., Kruger, R., Krut, O., Ktistakis, N. T., Kuan, C. Y., Kucharczyk, R., Kumar, A., Kumar, R., Kumar, S., Kundu, M., Kung, H. J., Kurz, T., Kwon, H. J., La Spada, A. R., Lafont, F., Lamark, T., Landry, J., Lane, J. D., Lapaquette, P., Laporte, J. F., Laszlo, L., Lavandero, S., Lavoie, J. N., Layfield, R., Lazo, P. A., Le, W., Le Cam, L., Ledbetter, D. J., Lee, A. J., Lee, B. W., Lee, G. M., Lee, J., Lee, J. H., Lee, M., Lee, M. S., Lee, S. H., Leeuwenburgh, C., Legembre, P., Legouis, R., Lehmann, M., Lei, H. Y., Lei, Q. Y., Leib, D. A., Leiro, J., Lemasters, J. J., Lemoine, A., Lesniak, M. S., Lev, D., Levenson, V. V., Levine, B., Levy, E., Li, F., Li, J. L., Li, L., Li, S., Li, W., Li, X. J., Li, Y. B., Li, Y. P., Liang, C., Liang, Q., Liao, Y. F., Liberski, P. P., Lieberman, A., Lim, H. J., Lim, K. L., Lim, K., Lin, C. F., Lin, F. C., Lin, J., Lin, J. D., Lin, K., Lin, W. W., Lin, W. C., Lin, Y. L., Linden, R., Lingor, P., Lippincott-Schwartz, J., Lisanti, M. P., Liton, P. B., Liu, B., Liu, C. F., Liu, K., Liu, L., Liu, Q. A., Liu, W., Liu, Y. C., Liu, Y., Lockshin, R. A., Lok, C. N., Lonial, S., Loos, B., Lopez-Berestein, G., Lopez-Otin, C., Lossi, L., Lotze, M. T., Low, P., Lu, B., Lu, B., Lu, B., Lu, Z., Luciano, F., Lukacs, N. W., Lund, A. H., Lynch-Day, M. A., Ma, Y., Macian, F., MacKeigan, J. P., Macleod, K. F., Madeo, F., Maiuri, L., Maiuri, M. C., Malagoli, D., Malicdan, M. C., Malorni, W., Man, N., Mandelkow, E. M., Manon, S., Manov, I., Mao, K., Mao, X., Mao, Z., Marambaud, P., Marazziti, D., Marcel, Y. L., Marchbank, K., Marchetti, P., Marciniak, S. J., Marcondes, M., Mardi, M., Marfe, G., Marino, G.a, Markaki, M., Marten, M. R., Martin, S. J., Martinand-Mari, C., Martinet, W., Martinez-Vicente, M., Masini, M., Matarrese, P., Matsuo, S., Matteoni, R., Mayer, A., Mazure, N. M., McConkey, D. J., McConnell, M. J., McDermott, C., McDonald, C., McInerney, G. M., McKenna, S. L., McLaughlin, B., McLean, P. J., McMaster, C. R., McQuibban, G. A., Meijer, A. J., Meisler, M. H., Melendez, A., Melia, T. J., Melino, G., Mena, M. A., Menendez, J. A., Menna-Barreto, R. F., Menon, M. B., Menzies, F. M., Mercer, C. A., Merighi, A., Merry, D. E., Meschini, S., Meyer, C. G., Meyer, T. F., Miao, C. Y., Miao, J. Y., Michels, P. A., Michiels, C., Mijaljica, D., Milojkovic, A., Minucci, S., Miracco, C., Miranti, C. K., Mitroulis, I., Miyazawa, K., Mizushima, N., Mograbi, B., Mohseni, S., Molero, X., Mollereau, B., Mollinedo, F., Momoi, T., Monastyrska, I., Monick, M. M., Monteiro, M. J., Moore, M. N., Mora, R., Moreau, K., Moreira, P. I., Moriyasu, Y., Moscat, J., Mostowy, S., Mottram, J. C., Motyl, T., Moussa, C. E., Muller, S., Muller, S., Munger, K., Munz, C., Murphy, L. O., Murphy, M. E., Musaro, A., Mysorekar, I., Nagata, E., Nagata, K., Nahimana, A., Nair, U., Nakagawa, T., Nakahira, K., Nakano, H., Nakatogawa, H., Nanjundan, M., Naqvi, N. I., Narendra, D. P., Narita, M., Navarro, M., Nawrocki, S. T., Nazarko, T. Y., Nemchenko, A., Netea, M. G., Neufeld, T. P., Ney, P. A., Nezis, I. P., Nguyen, H. P., Nie, D., Nishino, I., Nislow, C., Nixon, R. A., Noda, T., Noegel, A. A., Nogalska, A., Noguchi, S., Notterpek, L., Novak, I., Nozaki, T., Nukina, N., Nurnberger, T., Nyfeler, B., Obara, K., Oberley, T. D., Oddo, S., Ogawa, M., Ohashi, T., Okamoto, K., Oleinick, N. L., Oliver, F. J., Olsen, L. J., Olsson, S., Opota, O., Osborne, T. F., Ostrander, G. K., Otsu, K., Ou, J. H., Ouimet, M., Overholtzer, M., Ozpolat, B., Paganetti, P., Pagnini, U., Pallet, N., Palmer, G. E., Palumbo, C., Pan, T., Panaretakis, T., Pandey, U. B., Papackova, Z., Papassideri, I., Paris, I., Park, J., Park, O. K., Parys, J. B., Parzych, K. R., Patschan, S., Patterson, C., Pattingre, S., Pawelek, J. M., Peng, J., Perlmutter, D. H., Perrotta, I., Perry, G., Pervaiz, S., Peter, M., Peters, G. J., Petersen, M., Petrovski, G., Phang, J. M., Piacentini, M., Pierre, P., Pierrefite-Carle, V., Pierron, G., Pinkas-Kramarski, R., Piras, A., Piri, N., Platanias, L. C., Poggeler, S., Poirot, M., Poletti, A., Pous, C., Pozuelo-Rubio, M., Praetorius-Ibba, M., Prasad, A., Prescott, M., Priault, M., Produit-Zengaffinen, N., Progulske-Fox, A., Proikas-Cezanne, T., Przedborski, S., Przyklenk, K., Puertollano, R., Puyal, J., Qian, S. B., Qin, L., Qin, Z. H., Quaggin, S. E., Raben, N., Rabinowich, H., Rabkin, S. W., Rahman, I., Rami, A., Ramm, G., Randall, G., Randow, F., Rao, V. A., Rathmell, J. C., Ravikumar, B., Ray, S. K., Reed, B. H., Reed, J. C., Reggiori, F., Regnier-Vigouroux, A., Reichert, A. S., Reiners, J. J., Jr., Reiter, R. J., Ren, J., Revuelta, J. L., Rhodes, C. J., Ritis, K., Rizzo, E., Robbins, J., Roberge, M., Roca, H., Roccheri, M. C., Rocchi, S., Rodemann, H. P., Rodriguez de Cordoba, S., Rohrer, B., Roninson, I. B., Rosen, K., Rost-Roszkowska, M. M., Rouis, M., Rouschop, K. M., Rovetta, F., Rubin, B. P., Rubinsztein, D. C., Ruckdeschel, K., Rucker, E. B., 3rd, Rudich, A., Rudolf, E., Ruiz-Opazo, N., Russo, R., Rusten, T. E., Ryan, K. M., Ryter, S. W., Sabatini, D. M., Sadoshima, J., Saha, T., Saitoh, T., Sakagami, H., Sakai, Y., Salekdeh, G. H., Salomoni, P., Salvaterra, P. M., Salvesen, G., Salvioli, R., Sanchez, A. M., Sanchez-Alcazar, J. A., Sanchez-Prieto, R., Sandri, M., Sankar, U., Sansanwal, P., Santambrogio, L., Saran, S., Sarkar, S., Sarwal, M., Sasakawa, C., Sasnauskiene, A., Sass, M., Sato, K., Sato, M., Schapira, A. H., Scharl, M., Schatzl, H. M., Scheper, W., Schiaffino, S., Schneider, C., Schneider, M. E., Schneider-Stock, R., Schoenlein, P. V., Schorderet, D. F., Schuller, C., Schwartz, G. K., Scorrano, L., Sealy, L., Seglen, P. O., Segura-Aguilar, J., Seiliez, I., Seleverstov, O., Sell, C., Seo, J. B., Separovic, D., Setaluri, V., Setoguchi, T., Settembre, C., Shacka, J. J., Shanmugam, M., Shapiro, I. M., Shaulian, E., Shaw, R. J., Shelhamer, J. H., Shen, H. M., Shen, W. C., Sheng, Z. H., Shi, Y., Shibuya, K., Shidoji, Y., Shieh, J. J., Shih, C. M., Shimada, Y., Shimizu, S., Shintani, T., Shirihai, O. S., Shore, G. C., Sibirny, A. A., Sidhu, S. B., Sikorska, B., Silva-Zacarin, E. C., Simmons, A., Simon, A. K., Simon, H. U., Simone, C., Simonsen, A., Sinclair, D. A., Singh, R., Sinha, D., Sinicrope, F. A., Sirko, A., Siu, P. M., Sivridis, E., Skop, V., Skulachev, V. P., Slack, R. S., Smaili, S. S., Smith, D. R., Soengas, M. S., Soldati, T., Song, X., Sood, A. K., Soong, T. W., Sotgia, F., Spector, S. A., Spies, C. D., Springer, W., Srinivasula, S. M., Stefanis, L., Steffan, J. S., Stendel, R., Stenmark, H., Stephanou, A., Stern, S. T., Sternberg, C., Stork, B., Stralfors, P., Subauste, C. S., Sui, X., Sulzer, D., Sun, J., Sun, S. Y., Sun, Z. J., Sung, J. J., Suzuki, K., Suzuki, T., Swanson, M. S., Swanton, C., Sweeney, S. T., Sy, L. K., Szabadkai, G., Tabas, I., Taegtmeyer, H., Tafani, M., Takacs-Vellai, K., Takano, Y., Takegawa, K., Takemura, G., Takeshita, F., Talbot, N. J., Tan, K. S., Tanaka, K., Tanaka, K., Tang, D., Tang, D., Tanida, I., Tannous, B. A., Tavernarakis, N., Taylor, G. S., Taylor, G. A., Taylor, J. P., Terada, L. S., Terman, A., Tettamanti, G., Thevissen, K., Thompson, C. B., Thorburn, A., Thumm, M., Tian, F., Tian, Y., Tocchini-Valentini, G., Tolkovsky, A. M., Tomino, Y., Tonges, L., Tooze, S. A., Tournier, C., Tower, J., Towns, R., Trajkovic, V., Travassos, L. H., Tsai, T. F., Tschan, M. P., Tsubata, T., Tsung, A., Turk, B., Turner, L. S., Tyagi, S. C., Uchiyama, Y., Ueno, T., Umekawa, M., Umemiya-Shirafuji, R., Unni, V. K., Vaccaro, M. I., Valente, E. M., Van den Berghe, G., van der Klei, I. J., van Doorn, W., van Dyk, L. F., van Egmond, M., van Grunsven, L. A., Vandenabeele, P., Vandenberghe, W. P., Vanhorebeek, I., Vaquero, E. C., Velasco, G., Vellai, T., Vicencio, J. M., Vierstra, R. D., Vila, M., Vindis, C., Viola, G., Viscomi, M. T., Voitsekhovskaja, O. V., von Haefen, C., Votruba, M., Wada, K., Wade-Martins, R., Walker, C. L., Walsh, C. M., Walter, J., Wan, X. B., Wang, A., Wang, C., Wang, D., Wang, F., Wang, F., Wang, G., Wang, H., Wang, H. G., Wang, H. D., Wang, J., Wang, K., Wang, M., Wang, R. C., Wang, X., Wang, X., Wang, Y. J., Wang, Y., Wang, Z., Wang, Z. C., Wang, Z., Wansink, D. G., Ward, D. M., Watada, H., Waters, S. L., Webster, P., Wei, L., Weihl, C. C., Weiss, W. A., Welford, S. M., Wen, L. P., Whitehouse, C. A., Whitton, J. L., Whitworth, A. J., Wileman, T., Wiley, J. W., Wilkinson, S., Willbold, D., Williams, R. L., Williamson, P. R., Wouters, B. G., Wu, C., Wu, D. C., Wu, W. K., Wyttenbach, A., Xavier, R. J., Xi, Z., Xia, P., Xiao, G., Xie, Z., Xie, Z., Xu, D. Z., Xu, J., Xu, L., Xu, X., Yamamoto, A., Yamamoto, A., Yamashina, S., Yamashita, M., Yan, X., Yanagida, M., Yang, D. S., Yang, E., Yang, J. M., Yang, S. Y., Yang, W., Yang, W. Y., Yang, Z., Yao, M. C., Yao, T. P., Yeganeh, B., Yen, W. L., Yin, J. J., Yin, X. M., Yoo, O. J., Yoon, G., Yoon, S. Y., Yorimitsu, T., Yoshikawa, Y., Yoshimori, T., Yoshimoto, K., You, H. J., Youle, R. J., Younes, A., Yu, L., Yu, L., Yu, S. W., Yu, W. H., Yuan, Z. M., Yue, Z., Yun, C. H., Yuzaki, M., Zabirnyk, O., Silva-Zacarin, E., Zacks, D., Zacksenhaus, E., Zaffaroni, N., Zakeri, Z., Zeh, H. J., 3rd, Zeitlin, S. O., Zhang, H., Zhang, H. L., Zhang, J., Zhang, J. P., Zhang, L., Zhang, L., Zhang, M. Y., Zhang, X. D., Zhao, M., Zhao, Y. F., Zhao, Y., Zhao, Z. J., Zheng, X., Zhivotovsky, B., Zhong, Q., Zhou, C. Z., Zhu, C., Zhu, W. G., Zhu, X. F., Zhu, X., Zhu, Y., Zoladek, T., Zong, W. X., Zorzano, A., Zschocke, J., and Zuckerbraun, B. (2012) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8, 445-544

 

日本語総説

仁科隆史、中野裕康
細胞死に伴う酸化ストレスによる生体の恒常性維持機構.
実験医学, 30:578-582,2012

中野裕康、米原伸
細胞死研究を超えて
実験医学, 30:538-544,2012

中野裕康
ネクロプトーシスの分子機構
医学のあゆみ, 243:45-50,2012

仁科隆史、中野裕康
酸化ストレスによる生体の恒常性維持機構
実験医学増刊号「活性酸素・ガス状分子による恒常性制御と疾患」, 123-129, 羊土社, 2012

2011

1. Ushio, H., Ueno, T., Kojima, Y., Komatsu, M., Tanaka, S., Yamamoto, A., Ichimura, Y., Ezaki, J., Nishida, K., Komazawa-Sakon, S., Niyonsaba, F., Ishii, T., Yanagawa, T., Kominami, E., Ogawa, H., Okumura, K., and Nakano, H. (2011) Crucial role for autophagy in degranulation of mast cells. J Allergy Clin Immunol 127, 1267-1276 e1266

 

2. Tokunaga, F., Nakagawa, T., Nakahara, M., Saeki, Y., Taniguchi, M., Sakata, S., Tanaka, K., Nakano, H., and Iwai, K. (2011) SHARPIN is a component of the NF-kappaB-activating linear ubiquitin chain assembly complex. Nature 471, 633-636. Selected by "Faculty of 1000"

 

3. Piao, J. H., Hasegawa, M., Heissig, B., Hattori, K., Takeda, K., Iwakura, Y., Okumura, K., Inohara, N., and Nakano, H. (2011) Tumor Necrosis Factor Receptor-associated Factor (TRAF) 2 Controls Homeostasis of the Colon to Prevent Spontaneous Development of Murine Inflammatory Bowel Disease. J Biol Chem 286, 17879-17888. The papers of the week and top 20 papers of JBC of the year.

 

4. Nakano, H., and Ushio, H. (2011) An unexpected role for autophagy in degranulation of mast cells. Autophagy 7, 657-659

 

5. Kojima, Y., Nakayama, M., Nishina, T., Nakano, H., Koyanagi, M., Takeda, K., Okumura, K., and Yagita, H. (2011) Importin beta1 Protein-mediated Nuclear Localization of Death Receptor 5 (DR5) Limits DR5/Tumor Necrosis Factor (TNF)-related Apoptosis-inducing Ligand (TRAIL)-induced Cell Death of Human Tumor Cells. J Biol Chem 286, 43383-43393

 

6. Charbonney, E., Speight, P., Masszi, A., Nakano, H., and Kapus, A. (2011) beta-catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial-myofibroblast transition. Mol Biol Cell 22, 4472-4485

 

日本語総説

中野裕康
ROSによる細胞傷害と生体応答制御
炎症と免疫, 19:14-18,2011

2010

1. Missiou, A., Rudolf, P., Stachon, P., Wolf, D., Varo, N., Aichele, P., Colberg, C., Hoppe, N., Ernst, S., Munkel, C., Walter, C., Sommer, B., Hilgendorf, I., Nakano, H., Bode, C., and Zirlik, A. (2010) TRAF5 deficiency accelerates atherogenesis in mice by increasing inflammatory cell recruitment and foam cell formation. Circ Res 107, 757-766

 

2. Masszi, A., Speight, P., Charbonney, E., Lodyga, M., Nakano, H., Szaszi, K., and Kapus, A. (2010) Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3. J Cell Biol 188, 383-399.Selected by "Faculty of 1000"

 

3. Ando, K., Hasegawa, K., Shindo, K., Furusawa, T., Fujino, T., Kikugawa, K., Nakano, H., Takeuchi, O., Akira, S., Akiyama, T., Gohda, J., Inoue, J., and Hayakawa, M. (2010) Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling. FEBS J 277, 2051-2066

 

日本語総説

中野裕康
死細胞の発するシグナル
化学と生物, 48: 368-369,2010

仁科隆史、中島章人、中野裕康
細胞死と炎症
細胞工学, 29:804-809,2010

中野裕康
ROSによる細胞死および生体反応の調節
実験医学増刊号「細胞死研究 総集編」, 35-40, 羊土社, 2010

2009

1. Tanaka, S., and Nakano, H. (2009) NF-kappaB2 (p100) limits TNF-alpha-induced osteoclastogenesis. J Clin Invest 119, 2879-2881

 

2. Kraus, Z. J., Nakano, H., and Bishop, G. A. (2009) TRAF5 is a critical mediator of in vitro signals and in vivo functions of LMP1, the viral oncogenic mimic of CD40. Proc Natl Acad Sci U S A 106, 17140-17145

 

3. Blackwell, K., Zhang, L., Thomas, G. S., Sun, S., Nakano, H., and Habelhah, H. (2009) TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis. Mol Cell Biol 29, 303-314

 

2008

1. Sebe, A., Masszi, A., Zulys, M., Yeung, T., Speight, P., Rotstein, O. D., Nakano, H., Mucsi, I., Szaszi, K., and Kapus, A. (2008) Rac, PAK and p38 regulate cell contact-dependent nuclear translocation of myocardin-related transcription factor. FEBS Lett 582, 291-298

 

2. Sawada, T., Nishiyama, C., Kishi, T., Sasazuki, T., Komazawa-Sakon, S., Xue, X., Piao, J. H., Ogata, H., Nakayama, J., Taki, T., Hayashi, Y., Watanabe, M., Yagita, H., Okumura, K., and Nakano, H. (2008) Fusion of OTT to BSAC Results in Aberrant Up-regulation of Transcriptional Activity. J Biol Chem 283, 26820-26828

 

3. Nakajima, A., Kurihara, H., Yagita, H., Okumura, K., and Nakano, H. (2008) Mitochondrial Extrusion through the cytoplasmic vacuoles during cell death. J Biol Chem 283, 24128-24135

 

4. Nakajima, A., Kojima, Y., Nakayama, M., Yagita, H., Okumura, K., and Nakano, H. (2008) Downregulation of c-FLIP promotes caspase-dependent JNK activation and reactive oxygen species accumulation in tumor cells. Oncogene 27, 76-84

 

5. Hasegawa, M., Fujimoto, Y., Lucas, P. C., Nakano, H., Fukase, K., Nunez, G., and Inohara, N. (2008) A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation. EMBO J 27, 373-383

 

2007

1. Zirlik, A., Bavendiek, U., Libby, P., MacFarlane, L., Gerdes, N., Jagielska, J., Ernst, S., Aikawa, M., Nakano, H., Tsitsikov, E., and Schonbeck, U. (2007) TRAF-1, -2, -3, -5, and -6 are induced in atherosclerotic plaques and differentially mediate proinflammatory functions of CD40L in endothelial cells. Arterioscler Thromb Vasc Biol 27, 1101-1107

 

2. Sejas, D. P., Rani, R., Qiu, Y., Zhang, X., Fagerlie, S. R., Nakano, H., Williams, D. A., and Pang, Q. (2007) Inflammatory Reactive Oxygen Species-Mediated Hemopoietic Suppression in Fancc-Deficient Mice. J Immunol178, 5277-5287

 

3. Piao, J. H., Yoshida, H., Yeh, W. C., Doi, T., Xue, X., Yagita, H., Okumura, K., and Nakano, H. (2007) TNF receptor-associated factor 2-dependent canonical pathway is crucial for the development of Peyer's patches. J Immunol 178, 2272-2277

 

4. Mohan, S., Koyoma, K., Thangasamy, A., Nakano, H., Glickman, R. D., and Mohan, N. (2007) Low shear stress preferentially enhances IKK activity through selective sources of ROS for persistent activation of NF-kappaB in endothelial cells. Am J Physiol Cell Physiol 292, C362-371

 

5. Fan, L., Sebe, A., Peterfi, Z., Masszi, A., Thirone, A. C., Rotstein, O. D., Nakano, H., McCulloch, C. A., Szaszi, K., Mucsi, I., and Kapus, A. (2007) Cell Contact-dependent Regulation of Epithelial-Myofibroblast Transition via the Rho-Rho Kinase-Phospho-Myosin Pathway. Mol Biol Cell 18, 1083-1097

 

日本語総説

中野裕康、中島章人
NF-κBによる細胞死抑制のメカニズム
実験医学, 25:1190-1194,2007

中野裕康、井上純一郎
NF-κBの多彩な機能とその活性化のメカニズム.
実験医学, 25:1160-1165,2007

中野裕康
TNFレセプターファミリーを介するシグナル伝達
遺伝子医学MOOK「シグナル伝達病を知る」, 60-66,メデイカルドウ, 2007

2006

1. Wu, L., Nakano, H., and Wu, Z. (2006) The C-terminal activating region 2 of the Epstein-Barr virus-encoded latent membrane protein 1 activates NF-kappaB through TRAF6 and TAK1. J Biol Chem 281, 2162-2169

 

2. Suzuki, S., Singhirunnusorn, P., Nakano, H., Doi, T., Saiki, I., and Sakurai, H. (2006) Identification of TNF-alpha-responsive NF-kappaB p65-binding element in the distal promoter of the mouse serine protease inhibitor SerpinE2. FEBS Lett 580, 3257-3262

 

3. Nakano, H., Nakajima, A., Sakon-Komazawa, S., Piao, J. H., Xue, X., and Okumura, K. (2006) Reactive oxygen species mediate crosstalk between NF-kappaB and JNK. Cell Death Differ 13, 730-737

 

4. Nakajima, A., Komazawa-Sakon, S., Takekawa, M., Sasazuki, T., Yeh, W. C., Yagita, H., Okumura, K., and Nakano, H. (2006) An antiapoptotic protein, c-FLIP(L), directly binds to MKK7 and inhibits the JNK pathway. EMBO J 25, 5549-5559

 

5. Maeda, K., Nishiyama, C., Tokura, T., Nakano, H., Kanada, S., Nishiyama, M., Okumura, K., and Ogawa, H. (2006) FOG-1 represses GATA-1-dependent FcepsilonRI beta-chain transcription: transcriptional mechanism of mast-cell-specific gene expression in mice. Blood 108, 262-269

 

日本語総説

中野裕康、中島章人
NF-κBによる細胞死抑制のメカニズム
炎症と免疫, 14:328-334,2006

2005

1. Xue, X., Piao, J. H., Nakajima, A., Sakon-Komazawa, S., Kojima, Y., Mori, K., Yagita, H., Okumura, K., Harding, H., and Nakano, H. (2005) Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha. J Biol Chem 280, 33917-33925

 

2. Tabuchi, A., Estevez, M., Henderson, J. A., Marx, R., Shiota, J., Nakano, H., and Baraban, J. M. (2005) Nuclear translocation of the SRF co-activator MAL in cortical neurons: role of RhoA signalling. J Neurochem 94, 169-180

 

3. Noguchi, T., Takeda, K., Matsuzawa, A., Saegusa, K., Nakano, H., Gohda, J., Inoue, J., and Ichijo, H. (2005) Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death. J Biol Chem 280, 37033-37040

 

4. Nakano, H. (2005) A revival of old players. EMBO Rep 6, 126-127

 

5. Kim, N., Kadono, Y., Takami, M., Lee, J., Lee, S. H., Okada, F., Kim, J. H., Kobayashi, T., Odgren, P. R., Nakano, H., Yeh, W. C., Lee, S. K., Lorenzo, J. A., and Choi, Y. (2005) Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis. J Exp Med 202, 589-595

 

6. Chen, L. F., Williams, S. A., Mu, Y., Nakano, H., Duerr, J. M., Buckbinder, L., and Greene, W. C. (2005) NF-{kappa}B RelA Phosphorylation Regulates RelA Acetylation. Mol Cell Biol 25, 7966-7975

 

日本語総説

中野裕康
NF-κBとJNKのクロストーク
生化学, 77:29-32,2005

中野裕康
TNFα, LTα・β
用語ライブラリー「サイトカイン増殖因子」, 117-121, 羊土社, 2005

2004

1. Yamada, T., Suzuki, M., Satoh, H., Kihara-Negishi, F., Nakano, H., and Oikawa, T. (2004) Effects of PU.1-induced mouse calcium-calmodulin-dependent kinase I-like kinase (CKLiK) on apoptosis of murine erythroleukemia cells. Exp Cell Res 294, 39-50

 

2. So, T., Salek-Ardakani, S., Nakano, H., Ware, C. F., and Croft, M. (2004) TNF receptor-associated factor 5 limits the induction of Th2 immune responses. J Immunol 172, 4292-4297

 

3. Sasazuki, T., Okazaki, T., Tada, K., Sakon-Komazawa, S., Katano, M., Tanaka, M., Yagita, H., Okumura, K., Tominaga, N., Hayashizaki, Y., Okazaki, Y., and Nakano, H. (2004) Genome wide analysis of TNF-inducible genes reveals that antioxidant enzymes are induced by TNF and responsible for elimination of ROS. Mol Immunol 41, 547-551

 

4. Nakano, H. (2004) Signaling crosstalk between NF-kappaB and JNK. Trends Immunol 25, 402-405

 

5. Mattioli, I., Sebald, A., Bucher, C., Charles, R. P., Nakano, H., Doi, T., Kracht, M., and Schmitz, M. L. (2004) Transient and selective NF-kappa B p65 serine 536 phosphorylation induced by T cell costimulation is mediated by I kappa B kinase beta and controls the kinetics of p65 nuclear import. J Immunol 172, 6336-6344

 

6. Hu, J., Nakano, H., Sakurai, H., and Colburn, N. H. (2004) Insufficient p65 phosphorylation at S536 specifically contributes to the lack of NF-kappaB activation and transformation in resistant JB6 cells. Carcinogenesis 25, 1991-2003

 

7. Gil, J., Garcia, M. A., Gomez-Puertas, P., Guerra, S., Rullas, J., Nakano, H., Alcami, J., and Esteban, M. (2004) TRAF family proteins link PKR with NF-kappa B activation. Mol Cell Biol 24, 4502-4512

 

日本語総説

中野裕康
活性酸素によるNF-κBとJNKのクロストーク
臨床免疫, 42:317-324,2004

中野裕康
TNFファミリー分子とレセプター
キーワードで理解する免疫学イラストマップ, 168-176, 羊土社, 2004

2003

1. Sakurai, H., Suzuki, S., Kawasaki, N., Nakano, H., Okazaki, T., Chino, A., Doi, T., and Saiki, I. (2003) Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway. J Biol Chem 278, 36916-36923

 

2. Sakon, S., Xue, X., Takekawa, M., Sasazuki, T., Okazaki, T., Kojima, Y., Piao, J. H., Yagita, H., Okumura, K., Doi, T., and Nakano, H. (2003) NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death. EMBO J 22, 3898-3909

 

3. Saitoh, T., Nakayama, M., Nakano, H., Yagita, H., Yamamoto, N., and Yamaoka, S. (2003) TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB activation. J Biol Chem 278, 36005-36012

 

4. Okazaki, T., Sakon, S., Sasazuki, T., Sakurai, H., Doi, T., Yagita, H., Okumura, K., and Nakano, H. (2003) Phosphorylation of serine 276 is essential for p65 NF-kappaB subunit-dependent cellular responses. Biochem Biophys Res Commun 300, 807-812

 

5. Luftig, M., Prinarakis, E., Yasui, T., Tsichritzis, T., Cahir-McFarland, E., Inoue, J., Nakano, H., Mak, T. W., Yeh, W. C., Li, X., Akira, S., Suzuki, N., Suzuki, S., Mosialos, G., and Kieff, E. (2003) Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6. Proc Natl Acad Sci U S A 100, 15595-15600

 

6. Kanazawa, K., Azuma, Y., Nakano, H., and Kudo, A. (2003) TRAF5 functions in both RANKL- and TNFalpha-induced osteoclastogenesis. J Bone Miner Res 18, 443-450

 

7. Hur, G. M., Lewis, J., Yang, Q., Lin, Y., Nakano, H., Nedospasov, S., and Liu, Z. G. (2003) The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activation. Genes Dev 17, 873-882

 

8. Chen, M. C., Hwang, M. J., Chou, Y. C., Chen, W. H., Cheng, G., Nakano, H., Luh, T. Y., Mai, S. C., and Hsieh, S. L. (2003) The role of apoptosis signal-regulating kinase 1 in lymphotoxin-beta receptor-mediated cell death. J Biol Chem 278, 16073-16081

 

2002

1. Sasazuki, T., Sawada, T., Sakon, S., Kitamura, T., Kishi, T., Okazaki, T., Katano, M., Tanaka, M., Watanabe, M., Yagita, H., Okumura, K., and Nakano, H. (2002) Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death. J Biol Chem 277, 28853-28860

 

2. Saitoh, T., Nakano, H., Yamamoto, N., and Yamaoka, S. (2002) Lymphotoxin-beta receptor mediates NEMO-independent NF-kappaB activation. FEBS Lett 532, 45-51

 

3. Nakayama, M., Ishidoh, K., Kayagaki, N., Kojima, Y., Yamaguchi, N., Nakano, H., Kominami, E., Okumura, K., and Yagita, H. (2002) Multiple pathways of TWEAK-induced cell death. J Immunol 168, 734-743

 

4. Harada, N., Nakayama, M., Nakano, H., Fukuchi, Y., Yagita, H., and Okumura, K. (2002) Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells. Biochem Biophys Res Commun 299, 488-493

 

日本語総説

中野裕康
TNF/TNFレセプター
アポトーシスのすべて, 23-29, 科学評論社, 2002

2001

1. Tada, K., Okazaki, T., Sakon, S., Kobarai, T., Kurosawa, K., Yamaoka, S., Hashimoto, H., Mak, T. W., Yagita, H., Okumura, K., Yeh, W. C., and Nakano, H. (2001) Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death. J Biol Chem 276, 36530-36534

 

2. Seino, K., Setoguchi, Y., Ogino, T., Kayagaki, N., Akiba, H., Nakano, H., Taniguchi, H., Takada, Y., Yuzawa, K., Todoroki, T., Fukuchi, Y., Yagita, H., Okumura, K., and Fukao, K. (2001) Protection against Fas-mediated and tumor necrosis factor receptor 1-mediated liver injury by blockade of FADD without loss of nuclear factor-kappaB activation. Ann Surg 234, 681-688

 

3. Okazaki, T., Nakao, A., Nakano, H., Takahashi, F., Takahashi, K., Shimozato, O., Takeda, K., Yagita, H., and Okumura, K. (2001) Impairment of bleomycin-induced lung fibrosis in CD28-deficient mice. J Immunol 167, 1977-1981

 

4. Matsushima, A., Kaisho, T., Rennert, P. D., Nakano, H., Kurosawa, K., Uchida, D., Takeda, K., Akira, S., and Matsumoto, M. (2001) Essential role of nuclear factor (NF)-kappaB-inducing kinase and inhibitor of kappaB (IkappaB) kinase alpha in NF-kappaB activation through lymphotoxin beta receptor, but not through tumor necrosis factor receptor I. J Exp Med 193, 631-636

 

5. Honda, K., Nakano, H., Yoshida, H., Nishikawa, S., Rennert, P., Ikuta, K., Tamechika, M., Yamaguchi, K., Fukumoto, T., Chiba, T., and Nishikawa, S. I. (2001) Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis.J Exp Med 193, 621-630

 

日本語総説

左近幸子、中野裕康
TNFレセプターを介するシグナル伝達経路
炎症と免疫,9:55-60,2001 

岡崎達馬、中野裕康
TNF受容体を介するシグナル伝達経路
最新医学, 56:141-145,2001 

2000以前

1. Sanz, L., Diaz-Meco, M. T., Nakano, H., and Moscat, J. (2000) The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway. EMBO J 19, 1576-1586

 

2. Yamazaki, T., Hamano, Y., Tashiro, H., Itoh, K., Nakano, H., Miyatake, S., and Saito, T. (1999) CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells. J Biol Chem 274, 18173-18180

 

3. Nakano, H., Sakon, S., Koseki, H., Takemori, T., Tada, K., Matsumoto, M., Munechika, E., Sakai, T., Shirasawa, T., Akiba, H., Kobata, T., Santee, S. M., Ware, C. F., Rennert, P. D., Taniguchi, M., Yagita, H., and Okumura, K. (1999) Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation. Proc Natl Acad Sci U S A 96, 9803-9808

 

4. Morio, T., Hanissian, S. H., Bacharier, L. B., Teraoka, H., Nonoyama, S., Seki, M., Kondo, J., Nakano, H., Lee, S. K., Geha, R. S., and Yata, J. (1999) Ku in the cytoplasm associates with CD40 in human B cells and translocates into the nucleus following incubation with IL-4 and anti-CD40 mAb. Immunity 11, 339-348

 

5. Jin, D. Y., Giordano, V., Kibler, K. V., Nakano, H., and Jeang, K. T. (1999) Role of adapter function in oncoprotein-mediated activation of NF-kappaB. Human T-cell leukemia virus type I Tax interacts directly with IkappaB kinase gamma. J Biol Chem 274, 17402-17405

 

6. Hatakeyama, S., Kitagawa, M., Nakayama, K., Shirane, M., Matsumoto, M., Hattori, K., Higashi, H., Nakano, H., Okumura, K., Onoe, K., and Good, R. A. (1999) Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1. Proc Natl Acad Sci U S A 96, 3859-3863


7. Akiba, H., Oshima, H., Takeda, K., Atsuta, M., Nakano, H., Nakajima, A., Nohara, C., Yagita, H., and Okumura, K. (1999) CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells. J Immunol 162, 7058-7066>

 

8. Shindo, M., Nakano, H., Sakon, S., Yagita, H., Mihara, M., and Okumura, K. (1998) Assignment of IkappaB kinase beta (IKBKB) to human chromosome band 8p12-->p11 by in situ hybridization. Cytogenet Cell Genet 82, 32-33

 

9. Shindo, M., Nakano, H., Kuroyanagi, H., Shirasawa, T., Mihara, M., Gilbert, D. J., Jenkins, N. A., Copeland, N. G., Yagita, H., and Okumura, K. (1998) cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2. Biochem Biophys Res Commun 244, 285-292

 

10. Oshima, H., Nakano, H., Nohara, C., Kobata, T., Nakajima, A., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., Muto, T., Yagita, H., and Okumura, K. (1998) Characterization of murine CD70 by molecular cloning and mAb. Int Immunol 10, 517-526

 

11. Nishitoh, H., Saitoh, M., Mochida, Y., Takeda, K., Nakano, H., Rothe, M., Miyazono, K., and Ichijo, H. (1998) ASK1 is essential for JNK/SAPK activation by TRAF2. Mol Cell 2, 389-395

 

12. Nakano, H., Shindo, M., Sakon, S., Nishinaka, S., Mihara, M., Yagita, H., and Okumura, K. (1998) Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Proc Natl Acad Sci U S A 95, 3537-3542


13. Kashiwada, M., Shirakata, Y., Inoue, J. I., Nakano, H., Okazaki, K., Okumura, K., Yamamoto, T., Nagaoka, H., and Takemori, T. (1998) Tumor necrosis factor receptor-associated factor 6 (TRAF6) stimulates extracellular signal-regulated kinase (ERK) activity in CD40 signaling along a ras-independent pathway. J Exp Med 187, 237-244

14. Akiba, H., Nakano, H., Nishinaka, S., Shindo, M., Kobata, T., Atsuta, M., Morimoto, C., Ware, C. F., Malinin, N. L., Wallach, D., Yagita, H., and Okumura, K. (1998) CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase. J Biol Chem 273, 13353-13358


15. Nakano, H., Shindo, M., Yamada, K., Yoshida, M. C., Santee, S. M., Ware, C. F., Jenkins, N. A., Gilbert, D. J., Yagita, H., Copeland, N. C., and Okumura, K. (1997) Human TNF receptor-associated factor 5 (TRAF5): cDNA cloning, expression and assignment of the TRAF5 gene to chromosome 1q32. Genomics 42, 26-32

 

16. Aizawa, S., Nakano, H., Ishida, T., Horie, R., Nagai, M., Ito, K., Yagita, H., Okumura, K., Inoue, J., and Watanabe, T. (1997) Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation. J Biol Chem 272, 2042-2045

 

17. Nakano, H., Yamazaki, T., Miyatake, S., Nozaki, N., Kikuchi, A., and Saito, T. (1996) Specific interaction of topoisomerase II beta and the CD3 epsilon chain of the T cell receptor complex. J Biol Chem 271, 6483-6489

 

18. Nakano, H., Oshima, H., Chung, W., Williams-Abbott, L., Ware, C. F., Yagita, H., and Okumura, K. (1996) TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor. J Biol Chem 271, 14661-14664

 

19. Nakata, K., Sugie, T., Cohen, H., Nakano, H., and Aoki, M. (1995) Expansion of circulating gamma delta T cells in active sarcoidosis closely correlates with defects in cellular immunity. Clin Immunol Immunopathol 74, 217-222


20. Miyatake, S., Nakano, H., Park, S. Y., Yamazaki, T., Takase, K., Matsushime, H., Kato, A., and Saito, T. (1995) Induction of G1 arrest by down-regulation of cyclin D3 in T cell hybridomas. J Exp Med 182, 401-408

 

21. Ohno, H., Goto, S., Taki, S., Shirasawa, T., Nakano, H., Miyatake, S., Aoe, T., Ishida, Y., Maeda, H., Shirai, T., Rajewsky, K., and Saito, T. (1994) Targeted disruption of the CD3 eta locus causes high lethality in mice: modulation of Oct-1 transcription on the opposite strand. EMBO J 13, 1157-1165

 

22. Nakata, K., Sugie, T., Nakano, H., Sakai, T., and Aoki, M. (1994) Gamma-delta T cells in sarcoidosis. Correlation with clinical features. Am J Respir Crit Care Med 149, 981-988

 

23. Nakano, H., Yamazaki, T., Ikeda, M., Masai, H., Miyatake, S., and Saito, T. (1994) Purification of glutathione S-transferase fusion proteins as a non-degraded form by using a protease-negative E. coli strain, AD202. Nucleic Acids Res 22, 543-544

 

24. Nakano, H., Ohno, H., and Saito, T. (1994) Activation of phospholipase C-gamma 1 through transfected platelet-derived growth factor receptor enhances interleukin 2 production upon antigen stimulation in a T-cell line. Mol Cell Biol 14, 1213-1219

 

日本語総説

中野裕康
NF-κB/IκB/IKK
新用語ライブラリー「免疫」, 141-142, 羊土社, 2000

中野裕康
TNFレセプターファミリー/TRAFファミリー
新用語ライブラリー「免疫」, 212-213, 羊土社, 2000

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