メンバー

駒澤 幸子(生化学分野)

職歴

平成9年~12年
順天堂大学医学部免疫学講座 科学技術振興事業団
戦略的基礎研究推進事業 CREST技術員
平成12年~15年
順天堂大学医学部免疫学講座 科学技術振興事業団
戦略的創造研究推進事業 さきがけ(PREST)技術員
平成15年~24年
順天堂大学医学部免疫学講座 技術員
平成 24年~ 現在
東邦大学医学部生化学講座 技術員

原著論文

  • Piao, X., S. Komazawa-Sakon, T. Nishina, M. Koike, J.H. Piao, H. Ehlken, H. Kurihara, M. Hara, N. Van Rooijen, G. Schutz, M. Ohmuraya, Y. Uchiyama, H. Yagita, K. Okumura, Y.W. He, and H. Nakano. 2012. c-FLIP Maintains Tissue Homeostasis by Preventing Apoptosis and Programmed Necrosis. Sci Signal 5:ra93.
  • Nishina, T., S. Komazawa-Sakon, S. Yanaka, X. Piao, D.M. Zheng, J.H. Piao, Y. Kojima, S. Yamashina, E. Sano, T. Putoczki, T. Doi, T. Ueno, J. Ezaki, H. Ushio, M. Ernst, K. Tsumoto, K. Okumura, and H. Nakano. 2012. Interleukin-11 links oxidative stress and compensatory proliferation. Sci Signal 5:ra5.
  • Ushio, H., T. Ueno, Y. Kojima, M. Komatsu, S. Tanaka, A. Yamamoto, Y. Ichimura, J. Ezaki, K. Nishida, S. Komazawa-Sakon, F. Niyonsaba, T. Ishii, T. Yanagawa, E. Kominami, H. Ogawa, K. Okumura, and H. Nakano. 2011. Crucial role for autophagy in degranulation of mast cells. J Allergy Clin Immunol 127:1267-1276 e1266.
  • Sawada, T., C. Nishiyama, T. Kishi, T. Sasazuki, S. Komazawa-Sakon, X. Xue, J.H. Piao, H. Ogata, J. Nakayama, T. Taki, Y. Hayashi, M. Watanabe, H. Yagita, K. Okumura, and H. Nakano. 2008. Fusion of OTT to BSAC Results in Aberrant Up-regulation of Transcriptional Activity. J Biol Chem 283:26820-26828.
  • Nakano, H., A. Nakajima, S. Sakon-Komazawa, J.H. Piao, X. Xue, and K. Okumura. 2006. Reactive oxygen species mediate crosstalk between NF-kappaB and JNK. Cell Death Differ 13:730-737.
  • Nakajima, A., S. Komazawa-Sakon, M. Takekawa, T. Sasazuki, W.C. Yeh, H. Yagita, K. Okumura, and H. Nakano. 2006. An antiapoptotic protein, c-FLIP(L), directly binds to MKK7 and inhibits the JNK pathway. Embo J 25:5549-5559.
  • Xue, X., J.H. Piao, A. Nakajima, S. Sakon-Komazawa, Y. Kojima, K. Mori, H. Yagita, K. Okumura, H. Harding, and H. Nakano. 2005. Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha. J Biol Chem 280:33917-33925.
  • Sasazuki, T., T. Okazaki, K. Tada, S. Sakon-Komazawa, M. Katano, M. Tanaka, H. Yagita, K. Okumura, N. Tominaga, Y. Hayashizaki, Y. Okazaki, and H. Nakano. 2004. Genome wide analysis of TNF-inducible genes reveals that antioxidant enzymes are induced by TNF and responsible for elimination of ROS. Mol Immunol 41:547-551.
  • Sakon, S., X. Xue, M. Takekawa, T. Sasazuki, T. Okazaki, Y. Kojima, J.H. Piao, H. Yagita, K. Okumura, T. Doi, and H. Nakano. 2003. NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death. EMBO J 22:3898-3909.
  • Okazaki, T., S. Sakon, T. Sasazuki, H. Sakurai, T. Doi, H. Yagita, K. Okumura, and H. Nakano. 2003. Phosphorylation of serine 276 is essential for p65 NF-kappaB subunit-dependent cellular responses. Biochem Biophys Res Commun 300:807-812.
  • Sasazuki, T., T. Sawada, S. Sakon, T. Kitamura, T. Kishi, T. Okazaki, M. Katano, M. Tanaka, M. Watanabe, H. Yagita, K. Okumura, and H. Nakano. 2002. Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death. J Biol Chem 277:28853-28860.
  • Tada, K., T. Okazaki, S. Sakon, T. Kobarai, K. Kurosawa, S. Yamaoka, H. Hashimoto, T.W. Mak, H. Yagita, K. Okumura, W.C. Yeh, and H. Nakano. 2001. Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death. J Biol Chem 276:36530-36534.
  • Nakano, H., S. Sakon, H. Koseki, T. Takemori, K. Tada, M. Matsumoto, E. Munechika, T. Sakai, T. Shirasawa, H. Akiba, T. Kobata, S.M. Santee, C.F. Ware, P.D. Rennert, M. Taniguchi, H. Yagita, and K. Okumura. 1999. Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation. Proc Natl Acad Sci U S A 96:9803-9808.
  • Shindo, M., H. Nakano, S. Sakon, H. Yagita, M. Mihara, and K. Okumura. 1998. Assignment of IkappaB kinase beta (IKBKB) to human chromosome band 8p12-->p11 by in situ hybridization. Cytogenet Cell Genet 82:32-33.
  • Nakano, H., M. Shindo, S. Sakon, S. Nishinaka, M. Mihara, H. Yagita, and K. Okumura. 1998. Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Proc Natl Acad Sci U S A 95:3537-3542.

総説、著書

  • 左近幸子、中野裕康. 「TNFレセプターを介するシグナル伝達経路」炎症と免疫、9巻、pp55-pp60、2001
  • 進藤真久、左近幸子、中野裕康.「TNFレセプターファミリー」アレルギー科、7巻、pp167-pp172、1999
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